Dental and Medical Problems
2015, vol. 52, nr 1, January-March, p. 11–16
Publication type: editorial article
Oral Complications Due to Radiotherapy and Chemotherapy in Cancer Patients
Powikłania w jamie ustnej po radioterapii i chemioterapii u pacjentów leczonych onkologicznie
1 Department of Oral Pathology, Saveetha Dental College, India
Chemotherapy and radiation therapy are the most common treatments used for the management of cancer patients. It can be used individually or together as adjuncts when a treatment protocol is planned. Unfortunately, in the process of treating one disease, the patient will have to endure the complications and side effects of the treatment. Chemotherapy has a systemic effect, whereas radiotherapy only affects the site of irradiation. The oral cavity is almost always affected, especially in head and neck cancer patients. Complications such as mucositis, dysgeusia, osteoradionecrosis, oral infections and dental developmental abnormalities are just to name a few. These side effects can greatly affect the quality of life of a patient either before, during or after cancer treatment. Hence, it is of up most importance that a clinician is well-versed with the possible complications and works towards helping the patient go through his treatment as comfortably and pain-free as possible.
chemotherapy, oral complications, radiation therapy, mucositis
chemioterapia, radioterapia, powikłania w jamie ustnej, mucositis, popromienna martwica kości
- Watter A.L., Epstein J.B., Agulnik M.: Oral complications of targeted cancer therapies: a narrative literature review. Oral Oncol. 2011, 47, 441–448.
- Ruiz-Esquide G., Nervi B., Vargas A., Maiz A.: Treatment and prevention of cancer treatment related to oral mucositis. Rev. Med. Child. 2011, 139, 373–381.
- Lopez-Galindo M.P., Bagan J.V., Jimenez-Soriano Y., Alpiste F., Camps C.: Clinical evaluation of dental and periodontal status in a group of oncological patients before chemotherapy. Med. Oral Pathol. Oral Cir. Bucal. 2006, 11, e17–21.
- Volpato L.E.R., Silva T.C., Oliveira T.M., Sakai V.T., Machado M.A.: Radiation therapy and chemotherapyinduced oral mucositis. Rev. Bras. Otorrinolaringol. 2007, 7, 562–568.
- Biron P., Sebben C., Gourmet R., Chvetzoff G., Philip I., Blay J.Y.: Research controversies in management of oral mucositis. Support Care Cancer, 2000, 8, 68–71.
- Raber-Durlacher J.E.: Current practices for management of .oral mucositis in cancer patients. Support Care Cancer 1999, 7, 71–74.
- Parulekar W., Mackenzie R., Bjarnason G., Jordan R.C.K.: Scoring oral mucositis. Oral Oncol. 1998, 34, 63–71.
- Sonis S.T.: Mucositis as a biological process: a new hypothesis for the development of chemotherapy-induced somatotoxicity. Oral Oncol. 1998, 34, 39–43.
- Bensadoun R.J., Magne N., Marcy P.Y., Demard F.: Chemotherapy and radiotherapy induced mucositis in head and neck cancer patients: new trends in pathophysiology, prevention and treatment. Eur. Arch. Otorhinolaryngol. 2001, 258, 481–487.
- Lopez-Castano F., Onate-Sanchez R.E., Roldan-Chicano R., Cabrerizo-Merino M.C.: Measurement of secondary mucositisto oncohematologic treatment by means of different scale. Review. Med. Oral Pathol. Oral Cir. Bucal. 2005, 10, 412–421.
- Keefe D.M., Schubert M.M., Elting L.S., Sonis S.T., Epstein J.B., Raber-Durlacher J.E.: Updated clinical practice guidelines for prevention and treatment of mucositis. Cancer 2007, 109, 820–831.
- Epstein J.B., Tsang A.H., Warkentin D., Ship J.A.: The role of salivary function in modulating chemotherapyinduced oropharyngeal mucositis: A review of literature. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 2002, 94, 39–44.
- Lopez B.C., Esteve C.G., Sarrion Perez M.G.: Dental treatment considerations in chemotherapy patient. J. Clin. Exp. Dent. 2011, 3, e31–42.
- Flemming T.: Oral tissue changes of radiation oncology and their management. Dent. Clin. North Am. 1990, 34, 223–229.
- Cowart B.J.: Taste dysfunction: a practical guide for oral medicine. Oral Dis. 2011, 17, 2–6.
- Kumar D., Rastogi N.: Oral complications and its management during radiotherapy. Int. J. Head Neck Surg. 2011, 2, 109–113.
- Minicucci E.M., Lopes L.F., Crocci A.J.: Dental abnormalities in children after chemotherapy treatment for acute lymphoid leukemia. Leuk. Res. 2003, 27, 45–50.
- Avsar A., Elli M., Darka O., Pinarli G.: Long term effects on chemotherapy on caries formation, dental development and salivary factors in early childhood cancer survivors. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 2007, 104, 781–789.
- Otmani N.: Oral and maxillofacial side effects of radiation therapy on children. J. Canadian Dent. Assoc. 2007, 73, 257–261.
- Oguz A., Cetiner S., Karadeniz C., Alpasan C., Pinarli G.: Long term effects of chemotherapy on orodental structures in children with non-Hodgkin’s lymphoma. Eur. J. Oral Sci. 2004, 112, 8–11.
- Pamela J.H., Joel B.E., Georgia R.S.: Oral and dental management related to radiation therapy for head and neck cancer. J. Can. Dent. Assoc. 2003, 69, 585–590.
- Chrcanovic B.R., Reher P., Sousa A.A., Harris M.: Osteoradionecrosis of the jaws – a current overview – part 1: Physiopathology and risk and predisposing factors. Oral Maxillofac. Surg. 2010, 14, 3–16.
- Marx R.: Osteoradionecrosis: A new concept of its pathophysiology. J. Oral Maxillofac. Surg. 1986, 41, 283.
- Sciubba J.J., Goldenberg D.: Oral complications of radiotherapy. Lancet Oncol. 2006, 7, 175–183.
- Drake M.T., Clark B.L., Kholsa S.: Bisphosphonates: Mechanism of action and role in clinical practice. Mayo Clin. Proc. 2008, 83, 1032–1045.
- Singh V., Malik S.: Oral care of patients undergoing chemotherapy and radiotherapy: A review of clinical approach. Internet J. Radiol. 2007, 6, 5.
- Ruggiero S.L., Mehrotra B., Rosenberg T.J., Engroff S.L.: Osteonecrosis of the jaw associated with the use of bisphosphonates. A review of 63 cases. J. Oral Maxillofac. Surg. 2004, 65, 527–534.
- Migliorati C.A., Schuber M.M., Peterson D.E., Senda L.M.: Bisphosphonate associated osteonecrosis of mandibular and maxillary bon: An emerging oral complication of suppostive cancer therapy. Cancer 2005, 104, 83–93.
- Bagan J.V., Jimenez Y., Diaz J.M., Murillo J., Sanchis J.M., Poveda R.: Osteonecrosis of the jaws in intravenous bisphosphonate use: Proposal for a modification of the clinical classification. Oral Oncol. 2009, 45, 465–466.
- Mosel D.D., Bauer R.L., Lynch D.P., Hwang S.T.: Oral complications in treatment of cancer patients. Support Care Cancer 2003, 1, 48–55.
- Jensen S.B., Mouridsen H.T., Bergmann O., Reibel J,. Bunner N., Nauntofte B.: Oral mucosal lesions, microbial changes and taster disturbances induced by adjuvant chemotherapy in breast cancer patients. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 2008, 106, 217–226.
- Raber-Durlacher J.E., Epstein J.B., Raber J., van Diesel J.T., van Winkelhoff A.J., Guiot H.F.: Periodontal infection in cancer patients treated with high dose of chemotherapy. Support Care Cancer 2002, 10, 466–473.