Dental and Medical Problems

Dent. Med. Probl.
Index Copernicus (ICV) – 109.28, MNiSW – 11
Average rejection rate – 28.22
ISSN 1644-387X (print),   ISSN 2300-9020 (online)
Periodicity – quarterly

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Dental and Medical Problems

2019, vol. 56, nr 1, January-March, p. 105–110

doi: 10.17219/dmp/100507

Publication type: clinical case

Language: English

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Creative Commons BY-NC-ND 3.0 Open Access

Treatment of the facial basal cell carcinoma with the use of photodynamic therapy: A case report

Leczenie ogniska raka podstawnokomórkowego skóry twarzy z użyciem terapii fotodynamicznej – opis przypadku

Mateusz Trafalski1,B,D, Klaudia Kazubowska2,C,D, Kamil Jurczyszyn1,A,F

1 Department of Oral Surgery, Faculty of Dentistry, Wrocław Medical University, Poland

2 Academic Dental Polyclinic in Wrocław, Poland

Abstract

Basal cell carcinoma (BCC) is the most common skin cancer. It accounts for approx. 80% of human skin cancers and belongs to the group of non-melanoma skin cancers (NMSC). The highest incidence of this cancer is visible in older people, over 65 years of age. Photodynamic therapy (PDT) is a clinically approved method with a selective cytotoxic activity. It is used in the treatment of superficial forms of BCC, precancerous conditions (hyperkeratosis, actinic keratosis) and non-cancerous diseases (acne vulgaris, infection with herpes simplex virus – HSV, leukoplakia, lichen planus). The aim of the study was to apply PDT to a patient with a clinical diagnosis and histopathologically confirmed BCC. The patient, male, aged 82, reported to the Department of Oral Surgery at Wroclaw Medical University with BCC of dimensions 0.5 × 1.5 cm, present for 13 years in the area of the right mandibular angle, after previous surgical treatment. Photodynamic diagnosis (PDD) and PDT were employed using a semiconductor laser. 5-aminolevulinic acid (5-ALA) was used as a photosensitizer. The PDD and PDT procedures were applied at 2-week intervals for 3 months. Control visits after 3, 6 and 12 months did not show local recurrence. Photodynamic therapy is a highly useful, independent method of treating superficial forms of BCC.

Key words

basal cell carcinoma, photodynamic therapy, photodynamic diagnosis, aminolevulinic acid

Słowa kluczowe

rak podstawnokomórkowy, terapia fotodynamiczna, diagnostyka fotodynamiczna, kwas aminolewulinowy

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